His style is a bridge between the late Gothic period and the Northern Renaissance. He is a primary representative of Antwerp Mannerism, a style defined by elongated figures and theatrical compositions. De Cock was heavily influenced by Hieronymus Bosch, which is evident in his depictions of Saint Anthony. His works often feature bizarre creatures and rocky, fantastic environments. Unlike the more reserved religious art of his contemporaries, his scenes are filled with restless energy and strange, small details that require close inspection.

Modern collectors are drawn to the surreal qualities of his work. The strange creatures and distorted perspectives in pieces like The Temptation of Saint Anthony feel surprisingly contemporary. His use of colour and shadow creates a sense of drama that fits well in modern interiors. Because his works were originally intended for domestic spaces, they maintain an intimate scale that works well as fine art prints. These images provide a direct look at the sixteenth-century fascination with the supernatural.