Her work focuses on animal subjects and religious themes, including studies of livestock and celestial figures. Prestel used a combination of etching and aquatint to create subtle gradations of tone. This technical precision is visible in works like Two Cows, Two Sheep, and a Goat, where the texture of animal hair and the softness of the sky are rendered with clarity. Unlike the sharp lines of traditional engraving, her prints possess a painterly quality that captures light and shadow through ink saturation.

Modern collectors value Prestel for her technical mastery and her role as a self-sufficient woman in the history of printmaking. Her prints offer a calm, naturalist aesthetic for contemporary interiors. The subjects, ranging from pastoral scenes to botanical details like the Chalice Vine, provide a sense of historical character. These works represent a bridge between the precision of scientific illustration and the atmosphere of Neoclassical art.