A double portrait by Piero di Cosimo of the Sangallo brothers, Giuliano and Francesco, prominent figures in the Florentine Renaissance. The painting showcases the artist's skill in capturing the likenesses and personalities of his subjects.

This double portrait by Piero di Cosimo depicts Giuliano and Francesco Giamberti da Sangallo, two brothers who were prominent figures in the Florentine Renaissance. Giuliano was a celebrated architect and sculptor, while Francesco was a woodcarver and military engineer. The painting, executed in oil on panel, showcases the artist's skill in capturing the likenesses and personalities of his subjects. It is currently housed in the Rijksmuseum, Amsterdam. The composition is divided into two distinct panels, each portraying one of the brothers in profile. Giuliano, on the left, is shown with a black cap and grey hair, his gaze directed towards the centre. Francesco, on the right, wears a red cap and is depicted with a more aged appearance. The background features a detailed depiction of a Tuscan, Italian , which adds depth and context to the portraits. Piero di Cosimo's attention to detail is evident in the rendering of the brothers' facial features and clothing. The use of light and shadow creates a sense of realism, while the overall composition reflects the artistic conventions of the Early Renaissance. The inclusion of architectural plans and musical scores further identifies the brothers' professions and interests.