His artistic approach focused on the grotesque style, a form of ornamentation derived from ancient Roman ruins. Nicoletto composed decorative panels featuring birds and fish arranged in balanced, vertical sequences. These works demonstrate his skill as both an engraver and a painter. He often adapted figures from other masters but placed them within his own structured frameworks. His prints helped spread Italian design across Europe.

Modern collectors appreciate the rhythmic patterns and botanical accuracy found in his work. His animal studies offer a formalised way to introduce natural elements into a room. The earth-toned palette he used provides an understated aesthetic that suits contemporary interiors. These prints offer a direct link to the sixteenth-century French court and the technical precision of the Renaissance.