His approach to art was shaped by his mastery of architecture and sculpture. He is credited with designing the city of Pienza and the bronze angels for the Siena Duomo. In his paintings, such as S. Dorothy, there is a clear sense of structure and form. His work maintains the lyrical qualities of the Sienese school while incorporating the rigorous spatial logic of an architect. He prioritised technical accuracy in his drawings of machines. This influenced the way he rendered physical space and human figures.

Modern collectors value the intellectual depth of his compositions. His drawings and paintings provide a window into the mind of a Renaissance polymath who balanced aesthetics with practical engineering. The clean lines and structural clarity of his work suit contemporary interiors. These pieces offer a connection to the early Renaissance period without the heavy ornamentation found in later styles.