His work often focuses on dramatic historical narratives and classical mythology. In pieces like Margaret of Anjou Attacked in a Wood, he uses precise lines to convey tension and movement. Picot had a talent for translating the textures of fabric and skin into the medium of engraving. His Italian Seaport shows his ability to handle light and architectural scale. He avoided the heavy, dark tones common in earlier prints, preferring a lighter touch that suited eighteenth-century taste.

Modern collectors value Picot for the clarity and formal balance of his compositions. His prints provide a view into the theatrical storytelling of the Enlightenment. The subjects, ranging from the stoic Apollo to historical queens, offer a sense of classical order. These works function well in contemporary interiors because they combine historical weight with a clean, graphic quality. He produced prints that were accessible to the growing middle class of his time.