His work is defined by dramatic lighting and unusual perspectives. In pieces like The Conversion of St. Paul and The Presentation in the Temple, Orsi uses sharp contrasts between shadow and light to create tension. He frequently employed chiaroscuro to define form. His figures often appear in coiled or twisted poses. Unlike many of his contemporaries, Orsi was also an architect. This technical background is visible in the precise structural logic of his painted interiors and ruins.

Modern collectors value Orsi for his strange, almost surreal compositions. His ability to pack immense energy into small formats makes his work suitable for domestic spaces. Prints of his drawings and paintings, such as Ceres or his Adoration, offer a look at the transition from the High Renaissance to the experimental Mannerist period. The X-radiograph versions of his work provide a scientific perspective on his process. These images reveal the underlying structural decisions he made before applying paint.