Gribelin is best known for his series of engravings after Raphael's Cartoons at Hampton Court. He approached these monumental Renaissance works with the technical discipline of a decorative engraver. His plates for The Miraculous Draught of Fishes and Paul Preaching at Athens use a systematic hatching technique to translate oil paintings into monochrome lines. He often included architectural borders in his prints, treating the paper like a piece of engraved silver plate.

Modern collectors value Gribelin for the architectural quality of his compositions. His works, such as Hercules Rejects Pleasure and Chooses Virtue, provide a structured aesthetic that suits formal interiors. The crisp lines of his engravings remain sharp even in reproduction. These prints offer a way to display the compositions of the High Renaissance through the lens of eighteenth-century British craftsmanship.