His work belongs to the Bolognese school, which was characterised by a return to classical order and naturalism. Brizio frequently depicted Saint Roch in his compositions, showing the saint distributing alms or interceding for the sick. He preferred balanced arrangements where figures occupy the foreground with clarity. His use of light creates a sense of three-dimensional form without relying on heavy shadows. Works such as the Holy Family Returning from Egypt show his ability to place figures within a structured outdoor setting.

Modern collectors value Brizio for his draughtsmanship and the architectural logic of his scenes. His prints and paintings offer a window into the Counter-Reformation period when art aimed for legibility and emotional directness. The clean compositions fit well in contemporary interiors that favour order and historical depth. These works provide a connection to the academic traditions of 17th-century Bologna through a lens of technical precision.