His approach was based on Symbolism and a fascination with medieval narrative. Derkinderen rejected the fleeting nature of Impressionism in favour of clear lines and allegorical subjects. Works like De bouw van het schip Argo or Trap des Levens use flat planes of colour and rhythmic compositions to tell stories of human existence. He often collaborated with artists like Jan Veth, focusing on the decorative potential of the human figure.

Modern collectors find value in the graphic clarity and structured compositions of his work. These prints provide a sophisticated alternative to chaotic abstract styles. His ability to distill complex religious or mythological scenes into balanced, linear designs makes his art suitable for contemporary homes. The historical weight of his subjects remains accessible through his clean, almost architectural style of drawing.