His style is defined by a strict adherence to linear perspective and clear, geometric forms. He preferred a sharp clarity in his figures. These characters often appear with a sculptural quality against vast architectural backgrounds. Unlike the softer styles emerging in Venice or Rome during his later years, Palmezzano kept a firm, almost mathematical approach to composition. He used cool tones and balanced arrangements to create a sense of stillness in works like his Holy Family.

Modern collectors value the architectural logic and clean lines of these works. The technical precision of his compositions fits well in contemporary spaces that favour order and structure. His paintings offer a window into the transition between the early and High Renaissance. The X-radiograph studies of his Risen Christ reveal the careful planning beneath the paint. These prints provide a connection to the disciplined methods of a master who prioritised clarity over drama.