His artistic style evolved from the formal constraints of Late Mannerism toward the bold contrasts of the early Baroque. Works such as Joseph and Potiphar's Wife demonstrate his skill with figure painting and narrative tension. He often used sharp chiaroscuro to create a sense of volume. Baglione eventually abandoned this style to return to more traditional Roman methods. He later became the president of the Accademia di San Luca and wrote a definitive history of his contemporary artists.

Modern collectors appreciate Baglione for his technical precision and his role in the development of seventeenth-century art. His prints offer a window into the competitive atmosphere of papal Rome. The clear lines in his drawings, such as Studie voor een knielende apostel, show a disciplined approach to anatomy. His religious and mythological scenes provide a sophisticated alternative to more aggressive Baroque styles. These works bring a sense of historical weight to contemporary interiors.