His work often features a preoccupation with death and the monumental. In pieces like Tomb with Sphinxes and an Owl or his depictions of Egyptian-style pharaohs, he uses heavy shadows and vast scale to evoke a sense of awe. Desprez frequently utilised the aquatint technique to achieve subtle tonal variations in his prints. This method helped him capture the play of light in cavernous interiors, such as the Palazzo Serra in Genua, where sunlight pierces through dark, structured spaces.

Collectors today value Desprez for his ability to blend architectural precision with a dark, imaginative flair. His prints do not simply document buildings; they create atmospheric scenes that feel cinematic. The stark geometry of his compositions provides a sophisticated aesthetic for contemporary interiors. His interest in chimaeras and allegorical subjects offers a surrealist quality that remains relevant to those who appreciate art with a mysterious or gothic edge.