Vendramini mastered the stipple engraving technique, which uses small dots to create tonal gradations rather than solid lines. This method produces a soft effect that suits the reproduction of Old Master paintings. His plates after Sebastiano del Piombo, such as The Raising of Lazarus, demonstrate his ability to translate large-scale religious compositions into detailed prints. He focused on clarity and anatomical precision. His work often features a controlled use of light and shadow to define form.

Modern collectors value Vendramini for his technical skill in translating classical and religious subjects into accessible formats. His prints provide a connection to the traditions of Italian and English art history. The soft textures of stipple engraving offer a muted aesthetic that fits well in contemporary interiors. These works function as historical documents and decorative objects. They bring the compositions of the Renaissance and Baroque periods into a domestic setting with a refined, monochromatic palette.