His artistic approach changed during a two-year stay in Rome. He abandoned the softer styles of his early training to study the works of Michelangelo and Tintoretto. This influence is visible in his 1554 painting, Fall of the Rebel Angels. The work features crowded, muscular figures that appear to press against the surface of the panel. Floris moved away from the saturated colour of earlier Flemish painters. He preferred a more restrained palette that emphasised physical structure, even giving his demonic figures animal extremities.

Modern collectors are drawn to the tension and energy found in these Northern Renaissance compositions. The work of Floris provides a sense of drama through its active poses and complex arrangements. His ability to blend Italian monumentalism with northern naturalism creates a striking visual balance. These prints suit contemporary spaces that require art with a strong physical presence. The focus on human form and movement offers a clear alternative to the more static religious art of previous generations.