The artistic approach of Klotz is defined by his use of line to mimic the tonal shifts of fresco painting. In plates such as God Creating the Animals, he employs systematic hatching to define form. His engravings are interpretations that adapt the soft textures of paint into the sharp clarity of ink on paper. This Neoclassical method favoured clean edges and balanced compositions. Each print maintains the spatial logic of the original architecture while functioning as a standalone work of graphic art.

Modern collectors find value in the architectural quality of the work of Klotz. The prints offer a window into the Renaissance through an 18th-century lens. Their monochromatic palette and classical subject matter make them suitable for structured interior designs. These works appeal to those who appreciate the intersection of draughtsmanship and theology. Because they were originally part of a series, they are often displayed in groups to recreate the rhythmic sequence of the Vatican galleries.